| Week | Date | Time | Opponent | Outcome | |
|---|---|---|---|---|---|
| Pre | 8/14/15 | 7:30pm EDT | New York Giants | Win 23-10 | Box Score |
| Pre | 8/24/15 | 8:00pm EDT | at Tampa Bay Buccaneers | Loss 11-25 | Box Score |
| Pre | 8/29/15 | 7:30pm EDT | Chicago Bears | Win 21-10 | Box Score |
| Pre | 9/03/15 | 7:00pm EDT | at Indianapolis Colts | Win 9-6 | Box Score |
| 1 | 9/13/15 | 4:35pm EDT | at Oakland Raiders | Win 33-13 | Box Score |
| 2 | 9/20/15 | 1:00pm EDT | San Diego Chargers | Win 24-19 | Box Score |
| 3 | 9/27/15 | 1:00pm EDT | at Baltimore Ravens | Win 28-24 | Box Score |
| 4 | 10/04/15 | 1:00pm EDT | Kansas City Chiefs | Win 36-21 | Box Score |
| 5 | 10/11/15 | 1:00pm EDT | Seattle Seahawks | Win 27-24 (O.T.) | Box Score |
| 6 | 10/18/15 | 1:00pm EDT | at Buffalo Bills | Win 34-21 | Box Score |
| 7 | BYE WEEK | ||||
| 8 | 11/01/15 | 1:00pm EDT | at Pittsburgh Steelers | Win 16-10 | Box Score |
| 9 | 11/05/15 | 8:25pm EDT | Cleveland Browns | Win 31-10 | Box Score |
| 10 | 11/16/15 | 8:30pm EDT | Houston Texans | Loss 6-10 | Box Score |
| 11 | 11/22/15 | 7:30pm EDT | at Arizona Cardinals | Loss 31-34 | Box Score |
| 12 | 11/29/15 | 1:00pm EDT | St. Louis Rams | Win 31-7 | Box Score |
| 13 | 12/06/15 | 1:00pm EDT | at Cleveland Browns | Win 37-3 | Box Score |
| 14 | 12/13/15 | 1:00pm EDT | Pittsburgh Steelers | Loss 20-33 | Box Score |
| 15 | 12/20/15 | 4:25pm EDT | at San Francisco 49ers | Win 24-14 | Box Score |
| 16 | 12/28/15 | 8:30pm EDT | at Denver Broncos | Loss 17-20 (O.T.) | Box Score |
| 17 | 1/03/15 | 1:00pm EDT | Baltimore Ravens | Win 24-16 | Box Score |
| Wild Card | 1/09/16 | 8:15pm EDT | Pittsburgh Steelers | Loss 16-18 | Box Score |