| Week | Date | Time | Opponent | Outcome | |
|---|---|---|---|---|---|
| Pre | 8/12/16 | 7:30pm EDT | Minnesota Vikings | Loss 16-17 | Box Score |
| Pre | 8/18/16 | 7:30pm EDT | at Detroit Lions | Win 30-14 | Box Score |
| Pre | 8/28/16 | 8:00pm EDT | at Jacksonville Jaguars | Loss 21-26 | Box Score |
| Pre | 9/01/16 | 7:30pm EDT | Indianapolis Colts | Loss 10-13 | Box Score |
| 1 | 9/11/16 | 1:00pm EDT | at New York Jets | Win 23-22 | Box Score |
| 2 | 9/18/16 | 1:00pm EDT | at Pittsburgh Steelers | Loss 16-24 | Box Score |
| 3 | 9/25/16 | 1:00pm EDT | Denver Broncos | Loss 17-29 | Box Score |
| 4 | 9/29/16 | 8:25pm EDT | Miami Dolphins | Win 22-7 | Box Score |
| 5 | 10/09/16 | 4:25pm EDT | at Dallas Cowboys | Loss 14-28 | Box Score |
| 6 | 10/16/16 | 1:00pm EDT | at New England Patriots | Loss 17-35 | Box Score |
| 7 | 10/23/16 | 1:00pm EDT | Cleveland Browns | Won 31-17 | Box Score |
| 8 | 10/30/16 | 9:30am EDT | Washington Redskins | Tie 27-27 | Box Score |
| 9 | BYE WEEK | ||||
| 10 | 11/14/16 | 8:30pm EDT | at New York Giants | Loss 20-21 | Box Score |
| 11 | 11/20/16 | 1:00pm EDT | Buffalo Bills | Loss 12-16 | |
| 12 | 11/27/16 | 1:00pm EDT | at Baltimore Ravens | Loss 14-19 | |
| 13 | 12/04/16 | 1:00pm EDT | Philadelphia Eagles | Won 32-14 | |
| 14 | 12/11/16 | 1:00pm EDT | at Cleveland Browns | Won 23-10 | |
| 15 | 12/18/16 | 8:30pm EDT | Pittsburgh Steelers | Won 24-20 | |
| 16 | 12/24/16 | 8:25pm EDT | at Houston Texans | Loss 10-12 | |
| 17 | 1/01/17 | 1:00pm EDT | Baltimore Ravens | Won 27-10 |